Prolotherapy
Safe, Simple, Elegant, and Effective - The Non-Surgical Solution for Pain Relief and Tissue Repair.
If you suffer from chronic musculoskeletal pain, you may have heard of prolotherapy as a potential treatment option. This non-surgical approach involves injecting a solution into the affected area to stimulate the body's natural healing process. Prolotherapy is becoming an increasingly popular alternative to surgery or long-term use of pain medications. Learn more about this drug-free option offered and how it may benefit you.
What is Prolotherapy?
Prolotherapy is a non-surgical technique involving injections of dextrose to heal and repair painful and injured joints, ligaments and cartilage. “Prolo” is short for proliferation, because the therapy stimulates the bodies own growth and formation of new cells and tissue to help repair weakened and damaged structures in the body.
Prolotherapy is an effective treatment for many types of acute and chronic musculoskeletal pain. For patients who have been told their only options are surgery or life long use of pain medications, prolotherapy can be be a viable, drug-free, non-surgical option to regain function and eliminate pain.
Musculoskeletal pain often originates from areas of structural weakness, especially at sites where tendons and ligaments attach to bone. Tendons and ligaments stabilize joints, and when they are torn or stretched, the structures they are surrounding can become painful. This pain can last years, because once injured these structures commonly do not heal back to their original strength and stability. This creates a chronic pain generator that can worsen over time. In prolotherapy, the whole goal is to stimulate the bodies own repair of injured tendons and ligaments, resulting in decreased pain and disability.
How Does Prolotherapy Work?
The basic mechanism of prolotherapy is simple. A solution is injected into an injured area, which leads to local inflammation and triggers a healing cascade. This results in the deposition of new collagen, the material that forms ligaments and tendons. As this new collagen matures, it shrinks, tightening and strengthening the areas where it was injected.
What are some conditions that Prolotherapy has been used to treat?
Chronic Low Back Pain
Chronic Headaches
Ehler’s Danlos Syndrome
Knee pain
Ligament Sprains (i.e. chronic ankle sprains)
Neck Pain
Osteoarthritis
Plantar Fasciitis
Post-Surgery Pain
Rotator Cuff Injuries
Sports Injuries
Tendonitis
Tennis/Golfer’s Elbow
Unstable Joints
Whiplash Injuries
Wrist and Hand Pain
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ProloTherapy Resources and Research
A protocol for a randomized clinical trial assessing the efficacy of hypertonic dextrose injection (prolotherapy) in chronic ankle instability, Ongoing clinical trial evaluating the effectiveness of hypertonic dextrose injections (prolotherapy) for treating chronic ankle instability.
Effects of Hypertonic Dextrose Injection (Prolotherapy) in Lateral Elbow Tendinosis: A Systematic Review and Meta-analysis, 2022 systematic review and meta-analysis that showed Prolotherapy with hypertonic dextrose injections shows promising results in reducing pain and improving function in patients with lateral elbow tendinosis.
Hypertonic Dextrose Stimulates Chondrogenic Cells to Deposit Collagen and Proliferate, 2021 study demonstrating that hypertonic dextrose stimulates chondrogenic cells to deposit collagen and proliferate, supporting its use in prolotherapy for joint regeneration.
Efficacy of prolotherapy in comparison to other therapies for chronic soft tissue injuries: A systematic review and network meta-analysis, 2021 systematic review and meta-analysis demonstrate prolotherapy's superior efficacy compared to other treatments for chronic soft tissue injuries.
2016 Systematic Review consisting of fourteen RCTs, 1 case-control study, and 18 case series studies.
“Use of dextrose prolotherapy is supported for treatment of tendinopathies, knee and finger joint OA, and spinal/pelvic pain due to ligament dysfunction.”Effectiveness and safety of prolotherapy injections for management of lower limb tendinopathy and fasciopathy: a systematic review, 2015 systematic review supports the effectiveness and safety of prolotherapy injections for managing lower limb tendinopathy and fasciopathy, offering a promising treatment option for chronic pain.
Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial, a 2013 study which demonstrated that prolotherapy resulted in clinically meaningful, sustained improvements in pain, function, and stiffness scores for knee osteoarthritis, compared to blinded saline injections and at-home exercises. This is arguably the most important prolotherapy study.
Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions
Injections to Kick-Start Tissue Repair, New York Times
GetProlo.com, numerous links and articles with further information